01 - Gently mix ground beef with kosher salt, black pepper, garlic powder, and onion powder in a bowl. Divide into 8 equal portions and form into balls.
02 - Preheat a large skillet or griddle over medium-high heat.
03 - Place 2 beef balls onto the hot skillet. Smash each flat with a spatula to form thin patties approximately the size of your tortillas. Cook for 1-2 minutes per side until browned and cooked through. Repeat with remaining beef. Set aside.
04 - Wipe the skillet clean and reduce heat to medium.
05 - Place a tortilla on a flat surface. Sprinkle 1/4 cup cheddar and 1/8 cup mozzarella on half of the tortilla. Top with a smashburger patty, diced pickles, red onion, and drizzle with ketchup, mustard, and mayonnaise. Add shredded lettuce and additional cheese if desired. Fold tortilla over to close.
06 - Melt a small amount of butter in the skillet. Cook each quesadilla for 2-3 minutes per side, pressing gently, until golden brown and cheese is melted. Repeat with remaining quesadillas.
07 - Slice each quesadilla in halves or quarters and serve immediately while hot.